Compared to other Australians, Aboriginal and Torres Strait Islander Australians continue to experience substantially poorer health outcomes. Population-based prevention activities are few and far between, resulting in a limited evidence base for primary prevention interventions. The Queensland Aboriginal and Islander Health Council (QAIHC) Centre for Clinical Research Excellence (CCRE) is undertaking a collaborative project that aims to support community controlled health services and other government and non-government service providers to develop, implement and evaluate a model of primary prevention specific to the needs of the local Aboriginal and Torres Strait Islander populations. This presentation will give an overview of the project, its objectives, anticipated outcomes and interim progress.